Building a Pangenome and Analysis of Structural Variation

           Pangenomics, or the analysis of multiple genomic assemblies at once, is the new gold standard in comparative genomics. Graph-genomes are a new type of data structure aimed at representing pangenomes that are steadily replacing the concept of reference genome. Indeed, graph-genomes provide a more comprehensive representation of genetic diversity and increased sensitivity to detect and characterize complex genetic variation. In this workshop, we will discuss the commonalities and differences of the main available methods and will build a genome-graph using the popular tool suite pggb. Using the graph-genome, we will further perform a search for structural variants and discuss downstream applications.

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